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Batch events & genealogy

MES-26073QA hold

Five source systems aligned on one elapsed-time axis. Hover anywhere to move a single crosshair across all tracks; click an event to inspect its source record.

Time window 0.0h to 280.0hActive gap [182.0, 182.7]T+0 = Oct 8 08:00 UTCDemo · read-only
Unit procedure UP-01Back to Batch 360
Frame BATCH-02

Synchronized execution trace

eBR · PI · CMMS · LIMS · operator log

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0h40h80h120h160h200h240h280h

Recipe phases

DeltaV eBR

Telemetry

OSIsoft PI · feed & head P

Maintenance

Maximo CMMS

QC pulls

LabWare LIMS

Operator log

eBR comments

T+264.4h spike

Feed rate (13–18 mL/min scale)Head pressure (0.7–1.6 bar scale)No telemetry (gap not drawn, not imputed here)Hover to read values

Event ledger

12 events · click a row to inspect, or open the owning record

WhenEventSystemDetailSourceOpen
Sep 26WO-8726Maximo CMMSTubing changeout on PM-204 during MES-26072 (Sep 26). Lot TS24-PT-5521 carried into this batch.Open PM-204
T+0.2hInoc. confirmedeBR commentsInoculation transfer confirmed by T. Reed; VCD 0.47 ×10⁶/mL.
T+72.0hQC-940LabWare LIMSVCD 5.6 ×10⁶/mL · viability 98.4%LIMS summary only
T+120.4hTemp shift ackeBR commentsTemperature shift to 34.0 °C acknowledged.
T+168.0hQC-944LabWare LIMSTiter 1.96 g/L · HMW 1.8% · acidic variants 24.1%
T+182.8hPI frozeneBR commentsPI trend frozen ~40 min; local HMI normal, no alarms. Automation notified.
T+212.1hPump chattereBR commentsAudible chatter at PM-204 head; flow PV within band. Preceded WO-8819.
T+215.2hWO-8819Maximo CMMSOcclusion clamp torque 0.42 → 0.55 N·m. Dynamic slip verification not performed (SOP-UP-014 §7.2 requires it).Open PM-204
T+216.0hQC-946LabWare LIMSGlucose 4.1 g/L · lactate 1.2 g/LLIMS summary only
T+262.0hQC-948 OOTLabWare LIMSHPLC Protein A titer 3.42 g/L (spec >3.80 g/L). Second-person review pending.Open QC-948
T+264.6hALM-UP-204 ackeBR commentsHEAD_P HI acknowledged. Feed PV 14.5 vs SP 16.9. MSAT on-call paged.
Oct 23 (plan)WO-8848 (planned)Maximo CMMSPlanned tubing changeout + slip verification during CIP turnaround Oct 23. Awaiting approval.Open PM-204

Selected event

WO-8819Observation

Occlusion clamp torque 0.42 → 0.55 N·m. Dynamic slip verification not performed (SOP-UP-014 §7.2 requires it).

HypothesisOver-occlusion after this adjustment is one candidate explanation for the later pressure rise; it is under review in INV-104, not established.

Open PM-204

Inoculum lineage

Working cell bank vial to production bioreactor

WCB-AB014-0217Vial 112 · thaw Sep 28SF-0928-AN-4 · 250 mLSF-0928-BN-4 · 250 mLSF-1001-CN-3 · 3 L flaskWB-07N-2 · 20 L rockingSUB-200-02N-1 · 200 L SUBBR-UP-01Production 2,000 L

Select BR-UP-01 to open the unit procedure. Other nodes open their genealogy record in the inspector.

Single-use & raw material lots

Scanned into eBR at point of use

MaterialLotCoA

Tubing · size 24 platinum silicone (PM-204)

Masterflex 96440-24 · Avantor · Installed Sep 26 (MES-26072)

Carried across 2 batches

TS24-PT-5521Released

Feed media

FM-AB014 · In-house · T+72h onward

Same lot used in MES-26072

Released

Basal media

BM-AB014 · In-house · Phase 01

BM-1184-03Released

Single-use bag 2,000 L

TB-2K-STD · Thermo Fisher · Phase 01

TB2K-26-0419Released

Vent filter 0.2 µm

FV-0.2-10 · Sartorius · Phase 01

Integrity test pass

FV-88213Released